Apigenin Scientific Studies

Summary: The study explores the impact of apigenin, a natural flavonoid, on NAD+ levels, aging, and sleep in various models. Apigenin elevates NAD+ levels by inhibiting CD38 and shows positive effects on learning, memory, and longevity in animal models. It also exhibits sedative effects and enhances survival in models of neurodegenerative disease. Human studies indicate that chamomile extract, containing apigenin, improves anxiety, mood, and pain relief.
Key Conclusion: Apigenin's diverse interactions with molecular pathways suggest potential benefits for aging and sleep, warranting further investigation.
Type: Review of animal and human clinical studies.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929570/

Summary: This study explores the multifaceted roles of apigenin, particularly its effects on NAD+ levels through CD38 inhibition, and its subsequent influence on aging, sleep, metabolism, and health in various models. It details apigenin's positive impacts on learning and memory, tumor inhibition, sedative effects, and longevity across different species, and its potential mechanisms of action through modulation of molecular pathways including GABA and inflammation.
Type: Research Review
Key Conclusion: Apigenin shows significant therapeutic potential, influencing sleep, longevity, and metabolic processes through its interaction with molecular pathways. Further research is necessary to fully understand its mechanisms and broader clinical applications.
Published: The study can be found on PubMed Central, enabling detailed exploration of apigenin's extensive implications for health and disease management.
Link: https://www.frontiersin.org/articles/10.3389/fnut.2024.1359176/full

Title: Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway
Summary: This study tested Apigenin in a mouse model of prostate cancer, finding it inhibited cancer progression by affecting key signaling pathways.
Type: Animal study
Dose and Duration: Administered at 20 and 50 μg/mouse/day for 20 weeks
Key Conclusion: Apigenin shows potential as a therapeutic agent by targeting cancer growth pathways in prostate cancer.
Link: Read the full study

Title: Apigenin blocks breast cancer cell growth
Summary: Investigated Apigenin's ability to inhibit growth and induce apoptosis in human breast cancer cells.
Type: Laboratory study (in vitro)
Key Conclusion: Demonstrates potential anti-cancer effects in breast cancer through growth inhibition and apoptosis induction.
Link: Read the full study

Title: Anti-inflammatory effects of Apigenin
Summary: Explored Apigenin's anti-inflammatory effects in various cellular models.
Type: Laboratory study (in vitro)
Key Conclusion: Apigenin may help reduce inflammation, which is beneficial for preventing chronic diseases.
Link: Read the full study

Title: Apigenin's preventive effects against cancer development
Summary: Reviews various studies showing Apigenin's potential in preventing different types of cancer.
Type: Review article
Key Conclusion: Provides evidence of Apigenin's role in cancer prevention, highlighting its therapeutic potential.
Link: Read the full study

Title: Apigenin impacts on colon cancer cells
Summary: Analyzes the impact of Apigenin on colon cancer cells, focusing on apoptosis and cell cycle arrest.
Type: Laboratory study (in vitro)
Key Conclusion: Apigenin can induce apoptosis and halt the cell cycle in colon cancer cells, suggesting its use as a supportive therapeutic option.
Link: Read the full study

Title: The Beneficial Role of Apigenin against Cognitive and Neurobehavioural Dysfunction
Summary: This systematic review compiles preclinical investigations to assess apigenin's effects on cognitive and neurobehavioural functions. It covers its anxiolytic and potential sleep-improving effects due to its action on various neurotransmitter systems.
Type: Systematic review of preclinical studies.
Key Conclusion: Apigenin shows promise in improving cognitive function, anxiety, and possibly sleep, through its neuroprotective properties.
Link: Read the full systematic review